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KMID : 0620920090410100757
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Experimental & Molecular Medicine
2009 Volume.41 No. 10 p.757 ~ p.764
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Interleukin-1β promotes the expression of monocyte chemoattractant protein-1 in human aorta smooth muscle cells via multiple signaling pathways
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Lim Jun-Hee
Um Hee-Jung
Park Jong-Wook
Lee In-Kyu
Kwon Taeg-Kyu
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Abstract
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Monocyte chemoattractant protein-1 (MCP1) plays a key role in monocyte/macrophage infiltration to the sub-endothelial space of the blood vessel wall, which is a critical initial step in atherosclerosis. In this study, we examined the intracellular signaling pathway of IL-1β-induced MCP1 expression using various chemical inhibitors. The pretreatment of a phosphatidylcholine (PC)-specific PLC (PC-PLC) inhibitor (D609), PKC inhibitors, or an NF-κB inhibitor completely suppressed the IL-1β-induced MCP1 expression through blocking NF-κB translocation to the nucleus. Pretreatment with inhibitors of tyrosine kinase or PLD partially suppressed MCP1 expression and failed to block nuclear NF-κB translocation. These results suggest that IL-1β induces MCP1 expression through activation of NF-κB via the PC-PLC/PKC signaling pathway.
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KEYWORD
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aorta, atherosclerosis, CCL2 protein, human, interleukin-1β, myocytes, smooth muscle, NF-κB, protein kinase C, type C phospholipase
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